Bezshapochny S, Bondarenko R
EFFECT OF QUERCETIN ON NASAL MUCOSAL DAMAGE IN CHRONIC ATROPHIC RHINITIS
Bezshapochny Sergey B.
Poltava State Medical University
Professor of Department of Otorhinolaryngology with Ophthalmology
Doctor of Medical Sciences, Professor.
Email: bezshapochny@ukr.net
ORCID ID: https://orcid.org/0000-0002-8726-2024
Scopus Author ID: 6603471609
Bondarenko Ruslan V
Poltava State Medical University
Department of Otorhinolaryngology with Ophthalmology
Postgraduate student
Email: motoman.110494@gmail.com
ORCID ID: https://orcid.org/0000-0002-8497-8123
Abstract
Atrophic rhinitis is a chronic disease of the nasal mucosa, which leads to metaplasia of the squamous epithelium, loss of goblet cells and occlusion of the vascular cavity. The treatment of chronic atrophic rhinitis is becoming more and more relevant and the need for correction. The standard approaches to the treatment of this problem and with the addition of quercetin were considered and compared. The impact on pathophysiological factors, changes in the intensity of lipid peroxidation, limitation of oxidative damage to proteins, changes in collagen and H2S content in the nasal mucosa was studied. Analysing the results of the study, we concluded that the addition of quercetin potentiates the reduction in the intensity of lipid peroxidation, limits oxidative damage to proteins, reduces the breakdown of collagen, and reduces the content of H2S in the nasal mucosa.
Key words: quercetin, atrophic rhinitis, lipid peroxidation, L-oxyproline, hydrogen sulfide.
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