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DOI 10.37219/2528-8253-2025-5-2

Zabolotna D, Smagina T, Nesterchuk V, Zarytska I
IMPACT OF HYPOTHYROIDISM AND DIABETES ON THE COURSE OF CHRONIC RHINOSINUSITIS IN PATIENTS WITH A HISTORY OF COVID-19
Zabolotna Diana D
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Med-ical Science of Ukraine”; Kyiv, Ukraine.
Head of Department of Rhinology and Allergology with a group of radiology
Doctor of Medical Sciences, Professor
E-mail: dianazab@ukr.net
ORCID ID: https://orcid.org/0000-0001-7807-8148
Scopus Author ID: 57208163951
Smagina Tetyana V
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”
Department of Rhinology and Allergology with radiology group
Candidate of Medical Sciences
Email: smagin1@ukr.net
ORCID ID: https://orcid.org/0000-0002-8349-8275
Nesterchuk Vladislav I
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
Department of Rhinology and Allergology with radiology group
Candidate of Medical Sciences
Email: smagin1@ukr.net
ORCID ID: https://orcid.org/0000-0003-4486-046X

Abstract

Background: Hormonal imbalance can significantly affect the physiology of the upper respiratory tract. There is also a correlation between respiratory coronavirus infection COVID-19 and other pathologies of the respiratory tract, in particular chronic rhinosinusitis (CRS). There is a need to study the features of the course of chronic rhinosinusitis and its treatment against the background of concomitant endocrine pathology and a history of COVID-19.

Objective: This study was aimed to determine the characteristics of the course of chronic rhinosinusitis against the background of concomitant endocrine pathology in patients who have had COVID-19, and the effectiveness of treatment of patients with CRS and concomitant hypothyroidism and diabetes.

Materials and methods: All patients in the study were divided into two groups of 40 people. The 1st group included patients with chronic rhinosinusitis and concomitant hypothyroidism and/or diabetes mellitus. The results of the examination and surgical treatment of patients with CRS in the 1st group were compared with those among patients with CRS without concomitant endocrine pathology (group 2). To determine the characteristics of the course of CRS among patients in the study groups, an assessment of the characteristics of the anamnesis and clinical manifestations of CRS, the quality of life of patients using the SNOT-22 questionnaire, a saccharin test to assess the state of mucociliary clearance in the nasal cavity during the initial examination and 3 months after surgical treatment were used. 3 months after treatment, the degree of improvement of the patient’s condition was assessed using the CGI-I scale.

Results and discussion: Among patients with concomitant endocrine pathology, there was a negative impact of the coronavirus infection on the course of CRS, which was manifested in the subjective worsening of CRS symptoms and slower recovery from exacerbation of CRS after COVID-19 episodes. CRS in patients with concomitant endocrine pathology is characterized by a more severe clinical course, worse quality of life and slower recovery after surgical treatment.

It was determined that patients with thyroid dysfunction and diabetes mellitus have a slower recovery of mucociliary clearance after surgery for CRS compared to patients without concomitant endocrine pathology

According to the analysis of the SNOT-22 questionnaire, concomitant thyroid hormone imbalance and diabetes contribute to a worse quality of life in patients with CRS, in particular after surgical treatment

Conclusions: Thus, one of the conditions for effective treatment of patients with CRS on the background of hypothyroidism and diabetes mellitus is timely detection and adequate compensation of the existing hormonal dysfunction. In the case of an unfavorable clinical course of CRS, slow postoperative recovery and rapid recurrence after surgery, patients should be examined for subclinical endocrine pathology.

Keywords: chronic rhinosinusitis, COVID-19, hypothyroidism, diabetes mellitus

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