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№6(6) 2023

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DOI 10.37219/2528-8253-2023-6-91

Медведєв ВВ
РЕГЕНЕРАЦІЙНА СЛАБКІСТЬ ВНУТРІШНЬОГО ВУХА І БІОІНЖЕНЕРНЕ ВІДНОВЛЕННЯ СЛУХУ:
КОРОТКИЙ ОГЛЯД ПРОБЛЕМИ
Медведєв Володимир Вікторович
Національний медичний університет імені О.О. Богомольця
Професор кафедри нейрохірургії
доктор медичних наук, професор
Email: vavo2010@gmail.com
ORCID ID: https://orcid.org/0000-0001-7236-3191
Scopus Author ID: 57195130399
ResearcherID: P-7278-2018

Анотація

Будова органу слуху поєднує простоту і глибину, залишаючись у багатьох питаннях предметом активного наукового пошуку. Онтогенез цього добірного механізму регулюється складними і ще не вповні зрозумілими механізмами. Технологічний інструментарій сьогочасної біомедичної науки дозволяє не лише досліджувати, а й маніпулювати об’єктами клітинного і молекулярного рівня. У цій статті ми оглядаємо дані щодо реалістичності відновлення популяції слухових рецепторів людини і перспективні шляхи вирішення цього завдання. Крім того, ми пропонуємо відповідь на фундаментальне питання — чому при мізерній кількості відносно просто улаштованих рецепторних клітин внутрішнього вуха їхня популяція не відновлюється самостійно.

Ключові слова: спіральний орган, стовбурові клітини, прогенітори, порушення слуху, регенерація, біопротезування, біоінженерія.

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