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№6(6) 2023

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DOI 10.37219/2528-8253-2023-6-9

Zabolotna D, Gogunska I, Smagina T, Nesterchuk V
EFFICACY OF A NATURAL COMPLEX WITH RESPIRATORY PROBIOTIC LACTOBACILLUS HELVETICUS MIMLH5
AND HYALURONIC ACID IN CHRONIC PHARYNGITIS AND CHRONIC TONSILLITIS
Zabolotna Diana D
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine.
Head of Department of Rhinology and Allergology with a group of radiology
Doctor of Medical Sciences, Professor
Email: dianazab@ukr.net
ORCID ID:  https://orcid.org/0000-0001-7807-8148
Scopus Author ID: 57208163951
 
Gogunska Inna V
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
Center allergic diseases of the upper respiratory tract
Doctor of Medical Sciences, professor
Email: innagogunskaya@gmail.com
ORCID ID: https://orcid.org/0000-0001-6952-5057
Scopus ID: 57720990200
 
Smagina Tetyana V
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”
Department of Rhinology and Allergology with radiology group
Candidate of Medical Sciences
Email: smagin1@ukr.net
ORCID ID: https://orcid.org/0000-0002-8349-8275
 
Nesterchuk Vladislav I
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
Department of Rhinology and Allergology with radiology group
Candidate of Medical Sciences
Email: smagin1@ukr.net
ORCID ID: https://orcid.org/0000-0003-4486-046X

Abstract

Actuality: Patients with chronic pharyngitis and chronic tonsillitis represent a significant part of the daily practice of otorhinolaryngologists and family medicine doctors around the world.

Aim: To evaluate the efficacy of using a natural complex based on the respiratory probiotic Lactobacillus helveticus MiMlh5 and hyaluronic acid in patients with chronic pharyngitis and chronic tonsillitis.

Materials and methods: Adult patients with chronic pharyngitis (15 persons) and chronic tonsillitis (15 persons) received Lactoangin, which contains the respiratory probiotic Lactobacillus helveticus MiMlh5 and sodium hyaluronate, for 30 days. Clinical and microbiological research methods are used in the evaluation of the treatment result.

Results: At the end of the Lactoangin course, a significant regression of objective and subjective signs of chronic pharyngitis and tonsillitis was observed, as well as an increase in quality of life indicators compared to the initial study. Lactobacillus helveticus MiMlh5 promotes the restoration of the resident microflora of the oropharynx. No cases of side effects of Lactoangin were registered in the study.

Conclusions: The use of Lactoangin in the patients with chronic pharyngitis and chronic tonsillitis promotes the regression of objective and subjective clinical manifestations of the disease and improve the quality of patient’s life. According to the results of a microbiological study, Lactobacillus helveticus MiMlh5 contributes to the development of the displacement of pathogenic microorganisms and the restoration of the resident microflora of the oropharynx.

Keywords: Chronic pharyngitis, chronic tonsillitis, respiratory probiotic, Lactobacillus helveticus, sodium hyaluronate.

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