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DOI 10.37219/2528-8253-2024-2-50

Naumenko OM, Krynychko LR, Motailo OV

CHRONIC MAXILLARY RHINOSINUSITIS AND PERIODONTITIS: A SINGLE PATHOLOGICAL PROCESS OR SEPARATE DISEASES? A SYSTEMATIC REVIEW AND META-ANALYSIS

Naumenko Oleksandr 
National medical University named after O.O. Bogomolets, Kyiv, Ukraine
First vice-rector, Doctor of Medical Sciences, Professor, Corresponding member of the National Academy of Science of Ukraine
Email: naumenko16t@ukr.net
https://orcid.org/0000-0002-9001-7580
Scopus Author ID: 7005396556
Krynychko Liliia
Bogomolets National Medical University, Kyiv, Ukraine
Assistant of the Department of Otorhinolaryngology
MD, PhD
Email: krinichko@bigmir.net  
ORCID ID: https://orcid.org/0000-0002-2067-9925
Motaylo Oleksiy
Bogomolets National Medical University, Kyiv, Ukraine
Assistant of the Department of Otorhinolaryngology
MD, PhD
Email: motailo.oleksii@gmail.com
ORCID ID: https://orcid.org/0000-0001-6159-4285

Abstract

Relevance: According to various sources, odontogenic origins of chronic maxillary rhinosinusitis (CMRS) are found in 5-40% of all chronic rhinosinusitis cases. The authors’ data indicate that unilateral CMRS may suggest an odontogenic cause, confirmed upon further examination in 45-70% of cases. Causes of odontogenic CMRS can include various dental pathologies such as endodontic diseases, periodontitis, oroantral fistula, or foreign bodies (elements of filling material). This article specifically focuses on the associations between periodontitis and chronic rhinosinusitis.

Objective: To conduct a systematic review and analyze the existing literature to determine the possible association between chronic rhinosinusitis and periodontitis.

Materials and Methods: A systematic review and meta-analysis were conducted using PRISMA criteria. The quality of the original studies was assessed using the Newcastle-Ottawa Scale. Randomized controlled trials (RCTs) were evaluated with the Cochrane Risk of Bias Tool. Only studies with medium to high quality (evidence levels 1-2) were included in the final analysis.

Results: The final sample after selecting all relevant publications included 5 studies, all with an evidence level of 2b according to the Centre of Evidence-Based Medicine (CEBM) criteria. The meta-analysis of the provided data yielded a pooled odds ratio (Pooled OR) of 1.38 with a 95% confidence interval [1.16, 1.66]. The Q-statistic reached 41.19, and the I²-statistic was 87.86%.

Conclusions: A significant association between chronic periodontitis and CMRS was identified. The presence of periodontitis in patients increases the likelihood of developing CMRS by 38% on the side of the affected tooth.

Keywords: periodontitis, chronic rhinosinusitis, odontogenic rhinosinusitis, maxillary sinus.

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