№3(7) 2024

DOI 10.37219/2528-8253-2024-3-19

Shevchuk YuV, Tereshcenko ZhA
PRACTICAL EXPERIENCE OF USING NANO-SILVER PREPARATIONS IN COMPLEX TREATMENT OF CHILDREN
WITH ACUTE ADENOIDITIS
Shevchuk Yuriy V
Bogomolets National Medical University; Kyiv, Ukraine
Associate professor of the Department of Otorhinolaryngology
MD, Candidate of Medical Sciences
Email: yuralor@ukr.net
ORCID ID: https://orcid.org/0009-0002-5128-5125
 
Tereshchenko Zhanna A
Bogomolets National Medical University; Kyiv, Ukraine
Associate professor of the Department of Otorhinolaryngology
MD, PhD
E-mail: zhannusik.a@gmail.com  
ORCID ID: https://orcid.org/0000-0002-8893-1648

Abstract

Introduction: From 7 to 50% of children suffer from adenoiditis. Preference is given to conservative treatment.

Objective: Evaluation of the efficacy and safety of various methods of treatment of children with acute adenoiditis, including the use of Coldicept nanoSilver nasal spray as part of complex therapy.

Materials and methods: An observational study was conducted with the use of Coldicept nanoSilver nasal spray as part of the complex therapy of patients with acute adenoiditis. 220 children between the ages of 4 and 17 participated in the clinical study.

Results and discussion: The use of the medical device Coldicept nanoSilver nasal spray as part of complex therapy helps reduce the symptoms of adenoiditis and increase the effectiveness of treatment with virtually no side effects.  

Conclusions: The use of Coldicept nanoSilver nasal spray in the complex therapy of adenoiditis helps to reduce complaints and symptoms of the disease more quickly and increases the effectiveness of complex therapy.

Keywords: Coldisept nanoSilver nasal spray, adenoiditis, conservative treatment.

References

  1. Berlucchi M, Valetti L, Parrinello G, Nicolai P. Long-term follow-up of children undergoing topical intranasal steroid therapy for adenoidal hypertrophy. Int J Pediatr Otorhinolaryngol. 2008 Aug; 72(8):1171-5. doi: 10.1016/j.ijporl.2008.04.001.
  2. Bredun OYu. [Adenoiditis in children and its complications]. Suchasna pediatrii︠a︡. 2012;4:86-89. [Aticle in Ukrainian].
  3. Bruna T, Maldonado-Bravo F, Jara P, Caro N. Silver Nanoparticles and Their Antibacterial Applications. Int J Mol Sci. 2021;22(13):7202. doi: 10.3390/ijms22137202.
  4. Bugari RA, Baschir AS, Turcin LA, Chioreanu A, Mihali CV, Ilie AC, et al. Adenoidal bacterial biofilm in pediatric rhinosinusitis. Rom J Morphol Embryol. 2021;62(2):481-9. doi: 10.47162/RJME. 62.2.14.
  5. Burdusel AC, Gherasim O, Grumezescu AM, Mogoanta L, Ficai A, Andronescu E. Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview. Nanomaterials (Basel). 2018;8(9): 681. doi: 10.3390/nano8090681.
  6. Coldisept NanoSilver throat spray, Medical device. Instruction for the usage. Available from: https://coldisept.com.ua/instruction_throat.pdf. [In Ukrainian].
  7. Gierk B, Kohlmann S, Korenke K, Spangenberg L, Zenger M, Brähler E, Löwe B. The Somatic Symptom Scale-8 (SSS-8): a brief measure of somatic symptom burden. JAMA Intern Med. 2014 Mar; 174(3):399-407. doi: 10.1001/jamainternmed. 2013.12179.
  8. Kania RE, Lamers GE, Vonk MJ, Huy PT, Hiemstra PS, Bloemberg GV, Grote JJ. Demonstration of bacterial cells and glycocalyx in biofilms on human tonsils. Arch Otolaryngol Head Neck Surg. 2007;133(2):115-21. doi: 10.1001/archotol. 133.2.115.
  9. Кaung K, Ayaka H, Hiroaki I, Takayuki K, Kinnosuke Y, Shigeru M, et al. Silver Nanoparticles as Potential Antibiofilm Agents against Human Pathogenic Bacteria. Chemistry Letters. 2017;46:594-6. doi: https://doi.org/10.1246/cl.161198.
  10. Kim HY. Statistical notes for clinical researchers: Risk difference, risk ratio, and odds ratio. Restor Dent Endod. 2017;42(1):72-76. doi: 10.5395/rde. 2017.42.1.72.
  11. Kosakivska IA. [Difficulties in diagnosing adenoid vegetation in children]. Suchasna pediatrii︠a︡. 2018; 5:11-13. [Article in Ukrainian].
  12. Kosakovskyi AL, Havrylenko YuV. [A modern approach to the treatment of acute and chronic adenoiditis in children]. Ukraïnskyĭ medychnyĭ chasopys. 2014;2:71-75. [Article in Ukrainian].
  13. Kupko N. [Adenoids in a child: how to optimize treatment?]. Children’s doctor. 2018;3-4:39-44. [Article in Ukrainian].
  14. Laiko AA, Zabolotna DD, Kosakivska IA, Rautskis PA, Bereznyuk VV, et al. [Pharyngeal tonsil hypertrophy and chronic adenoiditis]. Kyiv: Logos; 2010. 146 p. [In Ukrainian].
  15. Laiko AA, Zabolotnyi DI, Melnikov OF, et al. [Adenoiditis]. Kyiv: Logos; 2010. 178 p. [In Ukrainian].
  16. Laiko AA, Zabolotnyi DI, Sinyachenko VV. [Scope and methods of examination of the objective status of children with ENT pathology]. Kyiv: Logos; 2020. 137 p. [In Ukrainian].
  17. Laiko AA, Kosakovskyi AL, Zabolotna DD, et al. [Children’s otorhinolaryngology]. Kyiv: Logos; 2013. 575 p. [In Ukrainian].
  18. Martinez-Castanon G-A, Nereyda N, Martinez-Gutierrez, F, Martinez JR, Ruiz F. Synthesis and antibacterial activity of silver nanoparticles with different sizes. J of Nanopart Res. 2008;10:1343-8. doi: https://doi.org/10.1007/s11051-008-9428-6.
  19. Мodrzynski M, Zawisza E. An analysis of the incidence of adenoid hypertrophy in allergic children. Int J Pediatr Otorhinolaryngol. 2007 May;71 (5):713-9. doi: 10.1016/j.ijporl.2006.12.018.
  20. Muteeb G, Rehman MT, Shahwan M, Aatif M. Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A Narrative Review. Pharmaceuticals (Basel). 2023;16(11): 1615. doi: 10.3390/ph16111615.
  21. Popovych VI, Beketova GV. [Mythical diagnoses in pediatrics: adenoiditis or nasopharyngitis? What is the correct diagnosis? Questions and answers]. Pediatrics. Eastern Europe. 2021;2(9):294-303. [Article in Russian].
  22. Ramsey T, Lai W, Guo E, Svider PF, Zuliani G, Eloy JA, Folbe AJ. Clinical trials in rhinosinusitis: Identifying areas for improvement. Laryngoscope. 2018;128(6):1281-6. doi: 10.1002/lary.26912.
  23. Rezende RM, Amato FS, Barbosa AP, Menezes UP, Rezende P, Ferriani VPL, et al. Does atopy influence the effectiveness of treatment of adenoid hypertrophy with mometasone furoate? Am J Rhinol Allergy. 2015 Jan-Feb;29(1):54-6. doi: 10. 2500/ajra.2015.29.4126.
  24. Schupper AJ, Nation J, Pransky S. Adenoidectomy in children: What Is the evidence and what is its role? Curr Otorhinolaryngol Rep. 2018;6(1):64-73. doi: 10.1007/s40136-018-0190-8.
  25. Sharma D, Misba L, Khan AU. Antibiotics versus biofilm: an emerging battleground in microbial communities. Antimicrob Resist Infect Control. 2019;8:76. doi: 10.1186/s13756-019-0533-3.
  26. Sharma S, Mohler J, Mahajan SD, Schwartz SA, Bruggemann L, Aalinkeel R. Microbial biofilm: A Review on formation, infection, antibiotic resistance, control measures, and innovative treatment. Microorganisms. 2023;11(6):1614. doi: 10.3390/microorganisms11061614.
  27. Sistrom CL, Garvan CW. Proportions, odds, and risk. Radiology. 2004 Jan;230(1):12-9. doi: 10. 1148/radiol.2301031028.
  28. Torretta S, Drago L, Marchisio P, Ibba T, Pignataro L. Role of biofilms in children with chronic adenoiditis and middle ear disease. J Clin Med. 2019; 8(5):671. doi: 10.3390/jcm8050671.
  29. Vagias WM. Likert-Type Scale Response Anchors. Clemson University. 2006. Available from: http://www.clemson.edu/centers-institutes/tourism/documents/sample-scales.pdf.
  30. Yurochko FB, Kopanska DB. [Modern diagnosis and treatment of adenoid diseases]. Zdorov’ya Ukrayini. 2021;4(60):31-32. [Article in Ukrainian].