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№6(6) 2023

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DOI 10.37219/2528-8253-2023-6-91

Medvediev VV
REGENERATIVE WEAKNESS OF THE INNER EAR AND BIOENGINEERED HEARING RESTORATION:
A BRIEF PROBLEM OVERVIEW
Medvediev Volodymyr Victorovych
Bogomolets National Medical University
Professor of the Department of Neurosurgery
Doctor of Medical Sciences, Professor
Еmail: vavo2010@gmail.com
ORCID ID: https://orcid.org/0000-0001-7236-3191
Scopus Author ID: 57195130399
ResearcherID: P-7278-2018

Abstract

The structure of the hearing organ combines simplicity and depth, remaining in many issues the subject of active scientific research. The ontogenesis of this exquisite mechanism is regulated by complex and still incompletely understood mechanisms. The technological tools of modern biomedical science allow not only to study, but also to work at the cellular and molecular level. In this article, we review data on the realism of restoring the population of human auditory receptors and promising ways to solve this problem. In addition, we offer an answer to a fundamental question – why, with a small number of relatively simply arranged receptor cells of the inner ear, their population is not self-restored.

Key words: spiral organ, stem cells, progenitors, hearing impairments, regeneration, bioprosthetics, bioengineering.

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